Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 8, Issue -, Pages D1219-D1226Publisher
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/1117
Keywords
FAK; PYK2; osteoclasts; integrins; signaling; review
Categories
Funding
- NIAMS NIH HHS [P30AR46031, AR48120, AR47830] Funding Source: Medline
Ask authors/readers for more resources
Integrin alpha(v)beta(3) plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alphavbeta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available