Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 57, Issue 7, Pages 287-291Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0753-3322(03)00082-9
Keywords
atherosclerosis; CD4 T helper cells; animal models
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Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density lipoproteins from lesions suggest that a cell-mediated immune reaction is taking place in atherosclerosis. This review provides an overview of our current understanding of the roles of CD4(+) T cell subpopulations in atherosclerosis. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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