A new and convenient one-step synthesis of the natural 3-deoxyanthocyanidins apigeninidin and luteolinidin chlorides from 2,4,6-triacetoxybenzaldehyde

The total synthesis of apigeninidin (1), luteolinidin (2) and 5,7-dihydroxyflavylium (5) chlorides is performed through a one step reaction from an acetylated derivative of a commercial reagent. Condensation reaction between 2,4,6-triacetoxybenzaldehyde and an acetophenone derivative in anhyd methanolic hydrogen chloride provides the 3-deoxyanthocyanidins in high yields.