One-pot organocatalytic direct asymmetric synthesis of γ-amino alcohol derivatives

This report describes the unprecedented use of unmodified aldehydes as donors in catalytic three component one-Pot asymmetric Mannich reactions. The Mannich-type reactions were also readily performed for the first time with both in situ generated and preformed N-PMP protected aromatic aldimines. The prolinecatalyzed reactions provided an efficient and very mild entry to either enantiomer of gamma-amino alcohol derivatives in high yield and stereoselectivity.