Journal
TETRAHEDRON
Volume 59, Issue 37, Pages 7337-7344Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(03)01138-4
Keywords
Sinularia leptoclados; S. parva; leptocladolide A-C; l-epileptocladolide; 7E-leptocladolide; soft coral
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Three new norcembrane-based diterpenoids, leptocladolides A (1), B (4) and C (5), along with five known metabolites 6-10, have been isolated from the dichloromethane extract of a Taiwanese soft coral Sinularia leptoclados. Furthermore, a chemical investigation on the dichloromethane extract of S. parva has resulted in the isolation of two new related isomers, 1-epi-leptocladolide A (2) and 7E-leptocladolide A (3), in addition to 1 and 7. The structures of new metabolites 1-5 were elucidated on the basis of extensive spectroscopic analyses and their relative stereochemistries were determined by NOESY experiments. The new metabolites I and 3 have been shown to exhibit significant cytotoxic activity against KB and Hepa59T/VGH cancer cell lines. (C) 2003 Elsevier Ltd. All rights reserved.
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