Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 51, Issue 19, Pages 5677-5679Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf0302714
Keywords
Lupinus argenteus; leguminosae; isoflavones; linolenic acid; antibacterial; potentiation; MDR pump; Staphylococcus aureus
Funding
- NIGMS NIH HHS [GM 49631, R01 GM 59903] Funding Source: Medline
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Isoflavones isolated from Lupinus argenteus were found to potentiate the antibacterial activity of alpha-linolenic acid, also found in the same plant. The isoflavones also potentiated the activity of the natural plant antibiotic berberine and the synthetic fluoroquinoline antibiotic norfloxacin. The isoflavones increased the uptake of berberine into Staphylococcus aureus cells, indicating that they may be inhibiting a multidrug resistance pump (MDR). Thus, L. argenteus contains a weak antibacterial and also MDR pump inhibitors, which increase its potency.
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