Journal
SCIENCE
Volume 301, Issue 5639, Pages 1537-1541Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1086695
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Funding
- NCI NIH HHS [CA84374] Funding Source: Medline
- NIAID NIH HHS [AI52218] Funding Source: Medline
- NIGMS NIH HHS [GM58196] Funding Source: Medline
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Antibiotic self-resistance mechanisms, which include drug elimination, drug modi. cation, target modi. cation, and drug sequestration, contribute substantially to the growing problem of antibiotic resistance among pathogenic bacteria. Enediynes are among the most potent naturally occurring antibiotics, yet the mechanism of resistance to these toxins has remained a mystery. We characterize an enediyne self-resistance protein that reveals a self-sacrificing paradigm for resistance to highly reactive antibiotics, and thus another opportunity for nonpathogenic or pathogenic bacteria to evade extremely potent small molecules.
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