Journal
BRITISH JOURNAL OF CANCER
Volume 89, Issue 6, Pages 1031-1034Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6601195
Keywords
hereditary breast cancer; angiogenesis; factor VIII; chemotheraphy; survival
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Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival ( relative risk 1.9, 95% CI: 1.2 - 3.0), particularly among women who received adjuvant chemotherapy ( 10-year survival 27 vs 69%, P = 0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.
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