Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 213, Issue 1-2, Pages 7-10Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(03)00124-2
Keywords
migraine; genetics; association study; LDL receptor; chromosome 19
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We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p 13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon IS. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n. (C) 2003 Elsevier Science B.V. All rights reserved.
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