Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 13, Issue 18, Pages 2985-2988Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00630-9
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A novel series of anilinopyrazoles has been designed based on the X-ray crystal structure analysis. Most compounds from this series not only show sub-nanomolar IC50 values for CDK2, but also demonstrate almost 1000-fold selectivity to other kinases including CDK1. (C) 2003 Elsevier Ltd. All rights reserved.
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