Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 19, Pages 10913-10918Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1833166100
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL68744, P01 HL068744] Funding Source: Medline
- NIAID NIH HHS [R01 AI043407, R21 AI042284, R01 AI043407-07, AI43407, AI42284, AI50953, R01 AI050953, R01 AI042284] Funding Source: Medline
- NINDS NIH HHS [NS44044, R01 NS044044] Funding Source: Medline
Ask authors/readers for more resources
CD1d-restricted natural killer T (NKT) cells are a subset of regulatory T cells that react with glycolipid antigens. Although preclinical studies have effectively targeted NKT cells for immunotherapy, little is known regarding the early in vivo response of these cells to antigenic stimulation. We have analyzed the early response of NKT cells to glycolipid antigens and bacterial infection by using specific reagents for tracking these cells. Our results demonstrate dramatic in vivo expansion and surface phenotype alterations after NKT cell activation with a-galactosylceramide. In addition, we show significant NK1.1 down-modulation on NKT cells in the setting of oral Salmonella infection. Our results indicate that in vivo activation of NKT cells leads to a dynamic response characterized by surface receptor down-modulation and expansion. These findings alter current understanding of NKT cell biology and should aid in the rational design of NKT cell-based immunotherapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available