Journal
NEUROSCIENCE LETTERS
Volume 348, Issue 3, Pages 163-166Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00788-2
Keywords
Alzheimer's disease; Parkinson's disease; STH gene; tau gene; polymorphisms; haplotype
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The saitohin (STH) gene is located in intron 9 of the tau protein gene. It has been postulated that the R allele of Q7R polymorphism at the Saitohin gene is over-represented in the homozygous state in sporadic Alzheimer's disease (AD). Tau protein was implicated in AD pathophysiology and the tau gene haplotype is probably connected with sporadic late-onset Parkinson's disease (PD). We analyzed the STH polymorphism and tau gene haplotype in 100 clinically diagnosed AD cases, 100 PD cases and 100 age-matched healthy controls. We found that the R allele of the STH gene is associated with the H2 haplotype of tau in all cases. Additionally we observed no correlation between R allele frequency and AD or PD. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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