Journal
FEBS LETTERS
Volume 552, Issue 1, Pages 17-22Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/s0014-5793(03)00778-6
Keywords
influenza m2; viral matrix protein; proton channel; conduction mechanism
Funding
- NIGMS NIH HHS [GM-54623] Funding Source: Medline
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The M2 proton channel from influenza A virus forms proton-selective ion channels, which are the target of the drug amantadine. Here, existing experimental data are quantitatively examined for insights into mechanisms to account for the pH-and voltage-dependences of M2 proton conduction. The analysis shows that a model involving protonation equilibria of His 37, including pH-dependent changes in the relative rates of diffusion on either side of the pore, is quantitatively able to account for recently reported electrophysiological data examining the pH-and voltage-dependences of Rostock and Weybridge strain M2 proton conduction. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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