Journal
ORGANIC LETTERS
Volume 5, Issue 19, Pages 3459-3462Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035234c
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- NCI NIH HHS [CA31841, CA31845] Funding Source: Medline
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[GRAPHICS] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.
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