Journal
ORGANIC LETTERS
Volume 5, Issue 19, Pages 3451-3454Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035212q
Keywords
-
Categories
Ask authors/readers for more resources
TMS-ynones are versatile synthetic equivalents of beta-keto aldehydes and can be readily synthesized in an atom-economical fashion by coupling (het)aroyl chlorides and (TMS)-acetylene with only one equiv (!) of triethylamine under Sonogashira conditions. This mild ynone synthesis is also a suitable entry to 2,4-disubstituted pyrimidines in the sense of a one-pot three-component reaction, i.e., a coupling-addition-cyclocondensation sequence.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available