4.8 Article

Solid-phase synthesis of disulfide heterodimers of peptides

Journal

ORGANIC LETTERS
Volume 5, Issue 19, Pages 3431-3434

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0300827

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The synthesis of the orthogonal disulfide template 1 and its use to synthesize unsymmetrical intermolecular disulfide bond peptides on a solid support are described. Application of template 1 to synthesize bioconjugates of cell permeable moieties based on the disulfide bond is demonstrated.

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