Journal
BMC CANCER
Volume 3, Issue -, Pages 1-6Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1471-2407-3-24
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Background: Tamoxifen is widely prescribed for the treatment of breast cancer. Its success has been attributed to the modulation of the estrogen receptor. I have previously proposed that the release of arachidonic acid from cells may also mediate cancer prevention. Methods: Rat liver cells were radiolabelled with arachidonic acid. The release of [H-3] arachidonic acid after various times of incubation of the cells with tamoxifen was measured. Results: Tamoxifen, at micromolar concentrations, stimulates arachidonic acid release. The stimulation is rapid and is not affected by pre-incubation of the cells with actinomycin or the estrogen antagonist ICI-182,780. Conclusions: The stimulation of AA release by tamoxifen is not mediated by estrogen receptor occupancy and is non-genomic.
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