Journal
FEBS LETTERS
Volume 552, Issue 2-3, Pages 141-144Publisher
WILEY
DOI: 10.1016/S0014-5793(03)00905-0
Keywords
nitric oxide; nitric oxide synthase; artemisinin; parthenolide; malaria; NF-kB; IkB-alpha
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Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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