Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1013, Issue 1-2, Pages 173-181Publisher
ELSEVIER
DOI: 10.1016/S0021-9673(03)00713-1
Keywords
proteomics; peptides; proteins
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The on-line coupling of capillary electrophoresis (CE) with electrospray-time-of-flight mass spectrometry (MS) has been used to obtain patterns of peptides and proteins present in the urine of healthy human individuals. This led to the establishment of a normal urine polypeptide pattern, consisting of 247 polypeptides, each of which was found in more than 50% of healthy individuals. Applying CE-MS to the analysis of urine of patients with kidney disease revealed differences in polypeptide pattern. Twenty-seven polypeptides were exclusively found in samples of patients. Another 13, present in controls, were missing. These data indicate that CE-MS can be applied as powerful tool in clinical diagnostics. (C) 2003 Elsevier B.V. All rights reserved.
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