Journal
BRAIN RESEARCH
Volume 985, Issue 2, Pages 198-201Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)03044-0
Keywords
free fatty acid; phospholipase; phospholipid; cerebroprotection; ischemia; HPLC
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Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) from patients with ischemic and hemorrhagic stroke (n=25) and in contemporary controls (n=73) were examined using HPLC. Concentrations of CSF FFAs from ischemic and hemorrhagic stroke patients obtained within 48 It of the insult were significantly greater than in control patients. Higher concentrations of polyunsaturated fatty acids (PUFAs) in CSF obtained within 48 h of insult were associated with significantly lower (P<0.05) admission Glasgow Coma Scale scores and worse outcome at the time of hospital discharge, using the Glasgow Outcome Scale (P<0.01). (C) 2003 Elsevier B.V. All rights reserved.
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