Journal
JOURNAL OF CELL BIOLOGY
Volume 162, Issue 7, Pages 1255-1266Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200305055
Keywords
organelle division; membrane fission; peroxisome assembly; peroxin; liposomes
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We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets of matrix proteins into different immature intermediates along the pathway causes the redistribution of a peroxisomal protein, acyl-CoA oxidase (Aox), from the matrix to the membrane. A significant redistribution of Aox occurs only in mature peroxisomes. Inside mature peroxisomes, the membrane-bound pool of Aox interacts with Pex16p, a membrane-associated protein that negatively regulates the division of early intermediates in the pathway. This interaction inhibits the negative action of Pex-16p, thereby allowing mature peroxisomes to divide.
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