Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 20, Pages 11394-11399Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1534710100
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Funding
- NCI NIH HHS [1R01CA97061-01, R01 CA097061] Funding Source: Medline
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0641037] Funding Source: National Science Foundation
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We implement a strategy for aligning two protein-protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein-protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori, harbor a large complement of evolutionarily conserved pathways, and that a large number of pathways appears to have duplicated and specialized within yeast. Analysis of these findings reveals many well characterized interaction pathways as well as many unanticipated pathways, the significance of which is reinforced by their presence in the networks of both species.
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