Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 20, Pages 11565-11570Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1934636100
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Funding
- NIAID NIH HHS [AI-18785, AI-17134, R37 AI018785, AI-52225, R56 AI018785, R01 AI018785, R01 AI017134, R01 AI052225, R56 AI017134, AI-22295, P01 AI022295] Funding Source: Medline
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The T cell alphabeta receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development of peptide-specific T cells is not intrinsic to thymocytes that undergo thymic-positive selection but is an outcome of eliminating, through negative selection, thymocytes bearing TCRs with extensive peptide cross-reactivity. Hence, thymic-negative selection imposes peptide specificity on the mature T cell repertoire.
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