Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 13, Issue 5, Pages 492-496Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2003.08.009
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Planarians can regenerate using a pluripotent stem cell system. This phenomenon provides a unique opportunity to understand gene regulation in the process of differentiation from pluripotent stem cells. Recent studies have made significant advances in our understanding of the pluripotent stem cell system in this model. In particular, a gene knockdown method by RNA interference enabled great progress in identifying genes involved in regeneration and stem cell regulation.
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