Journal
INFECTION AND IMMUNITY
Volume 71, Issue 10, Pages 6101-6103Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.10.6101-6103.2003
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Funding
- NIAID NIH HHS [1K08 AI 01758-01] Funding Source: Medline
- NIDCR NIH HHS [R01 DE 13980-01, R01 DE013523, R01 DE 13523, R01 DE013980] Funding Source: Medline
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Reintroducing URA3 to its native locus in Candida albicans not5, not3, bur2, and kell disruption mutants enabled us to directly compare strains with control strain CAI-12. We showed that URA3 position affected orotidine 5'-monophosphate decarboxylase activity, hyphal morphogenesis, adherence, and mortality in murine disseminated candidiasis. After URA3 was reintroduced to its native locus, only NOT5 could be conclusively ascribed a role in virulence.
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