Journal
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
Volume 32, Issue 5, Pages 306-308Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/03009740310003956
Keywords
myocarditis; systemic lupus erythematosus; i.v. cyclophosphamide
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We describe a Chinese woman who developed severe heart failure 3 years from the onset of systemic lupus erythematosus (SLE). Endomyocardial biopsy confirmed lupus myocarditis, with focal infiltrates of small lymphocytes and some polymorphic neutrophils. The conventional treatment for cardiac failure plus oral prednisolone failed to bring clinical and echocardiographical improvement until the addition of intravenous (i.v.) 'pulse' cyclophosphamide. Three weeks after i.v. cyclophosphamide treatment, there was significant improvement of her heart failure symptoms with improvement in the ejection fraction from 19% to 63%.
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