Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 13, Issue 5, Pages 537-542Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2003.08.001
Keywords
-
Categories
Funding
- Telethon [E.1029, 1322] Funding Source: Medline
Ask authors/readers for more resources
Mesoangioblasts are multipotent progenitors of mesodermal tissues that express the key marker of angiopoietic progenitors, Flk1 (VEGF-receptor 2), and are physically associated with the embryonic dorsal aorta in avian and mammalian species. When transplanted in vivo, they give rise to multiple differentiated mesodermal phenotypes. Their ability to extensively self-renew in vitro, while retaining multipotency, qualifies mesoangioblasts as a novel class of stem cells. Mesoangioblasts disclose not only an unexpected source of progenitors for skeletal muscle and a variety of other mesoderm-derived tissues, but also establish a lineage kinship between progenitors of vascular and extravascular mesodermal tissues, with important basic and applicative implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available