Journal
ARCHIVES OF NEUROLOGY
Volume 66, Issue 12, Pages 1447-1455Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archneurol.2009.266
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Funding
- National Institute on Aging [P50 AG16574, U01 AG06786, R01 AG11378]
- National Institute of Mental Health [K01 MH68351]
- Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program
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In the past 10 years, there has been a virtual explosion in the literature concerning the construct of mild cognitive impairment. The interest in this topic demonstrates the increasing emphasis on the identification of the earliest features of cognitive disorders such as Alzheimer disease and other dementias. Mild cognitive impairment represents the earliest clinical features of these conditions and, hence, has become a focus of clinical, epidemiologic, neuroimaging, biomarker, neuropathological, disease mechanism, and clinical trials, research. This review summarizes the progress that has been made while also recognizing the challenges that remain. Arch Neurol. 2009;66(12):1447-1455
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