Journal
IUBMB LIFE
Volume 55, Issue 10-11, Pages 591-597Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15216540310001628663
Keywords
nitric oxide; peroxynitrite; mitochondria; cytochrome oxidase; inhibition; cytochrome c oxidase; oxygen; K-m
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In the mid 1990s a number of research groups recognized that mitochondrial oxygen consumption could be reversibly inhibited by nitric oxide at the level of the enzyme cytochrome c oxidase. The inhibition was apparently competitive with respect to the oxygen concentration. This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase.
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