Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 7, Issue 5, Pages 580-585Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2003.08.009
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Csk and Src are two protein tyrosine kinases with similar amino acid sequences but very different structures and functions. Csk catalyzes a tail phosphorylation reaction on Src and thereby restrains Src's activity and oncogenic potential. Comparative analysis of the domain interactions in these enzymes provides a lesson in signalling diversity and mechanisms of enzyme regulation. The molecular basis of the specificity of Csk targeting the Sire tail appears to involve both local and long-range interactions and illustrates the complexity of selective targeting in post-translational modification.
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