Journal
BIOELECTROCHEMISTRY
Volume 61, Issue 1-2, Pages 99-107Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2003.07.001
Keywords
bioheat equation; thermal effects; Joule heating; electrochemotherapy; electrogenetherapy; electropermeabilization
Funding
- NCRR NIH HHS [1 R21 RR15252-01] Funding Source: Medline
Ask authors/readers for more resources
Tissue electroporation is a technique that facilitates the introduction of molecules into cells by applying a series of short electric pulses to specific areas of the body. These pulses temporarily increase the permeability of the cell membrane to small drugs and macromolecules. The goal of this paper is to provide information on the thermal effects of these electric pulses for consideration when designing electroporation protocols. The parameters investigated include electrode geometry, blood flow, metabolic heat generation, pulse frequency, and heat dissipation through the electrodes. Basic finite-element models were created in order to gain insight and weigh the importance of each parameter. The results suggest that for plate electrodes, the energy from the pulse may be used to adequately estimate the heating in the tissue. However, for needle electrodes, the geometry, i.e. spacing and diameter, and pulse frequency are critical when determining the thermal distribution in the tissue. (C) 2003 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available