Structure and pharmacology of swelling-sensitive chloride channels, ICl,swell

Since several years, the interest for chloride channels and more particularly for the enigmatic swelling-activated chloride channel (I-Cl.swell) is increasing. Despite its well-characterized electrophysiological properties, the I-Cl.swell structure and pharmacology. are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling-activatcd chloride channels.