Voltammetry and EQCM investigation of glutathione monolayer and its complexation with Cu2+

The glutathione (GSH) self-assembled monolayer and its compexlation with Cu2+ were studied by using voltammetry and EQCM. It was found that the monolayer could rearrange during the redox process Of Cu2+/Cu+. The protonating, or not, of the carboxyl terminates of the adsorpted GSH molecules influence the compexlation interaction significantly for they are the key binding sites. The GSH monolayer had the capacity to accumulate Cu2+ and the monolayer modified gold electrode was employed to detect the low levels of Cu2+ with a limit of 1.0 x 10(-10) mol L-1.