Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 266, Issue 1, Pages 215-218Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0021-9797(03)00570-8
Keywords
iron oxide; nanoparticle; protein isolation; avidin; biotin; MRI
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Synthetic approaches that vigorously control the microstructures of water-dispersible gamma-Fe2O3 nanoparticles such as size and size uniformity are of importance to the potential biological applications of these nanomaterials. In the present paper, water-dispersible y-Fe2O3 nanocrystals with narrow size distributions (bipy-Fe2O3) were prepared via a site-exchange reaction. These particular materials are superparamagnetic and stable within a wide range of pH. Introduction of the biotin functionality onto the surfaces of bipy-Fe2O3 enabled the affinity isolation of the protein avidin from its incubation solution magnetically with 96% efficiency. (C) 2003 Elsevier Inc. All rights reserved.
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