Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 4, Issue 10, Pages 757-766Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1230
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Over the past two years, it has become evident that there is an unexpected link between nuclear pore complex structure and dynamics, nucleocytoplasmic transport and chromosome segregation. In addition, a tomographic three-dimensional reconstruction of native nuclear pore complexes preserved in thick amorphous ice has unveiled a number of new structural features of this supramolecular machine. These data, together with some of the elementary physical principles that underlie nucleocytoplasmic transport, will be discussed in this review.
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