Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 71, Issue 2, Pages 305-312Publisher
WILEY-LISS
DOI: 10.1002/jmv.10484
Keywords
RSV infections; antigenic and genetic diversity; Uruguay; Argentina
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The antigenic and genetic diversity of G glycoprotein from 25 human respiratory viruses (group A) isolated during nine consecutive epidemics (1993-2001) in Montevideo, Uruguay, and 7 strains isolated in Buenos Aires, Argentina, in the same period were analyzed. Genetic variability was evaluated by partial sequence of the G protein gene. Phylogenetic analysis indicated that most Uruguayan and Argentinean group A isolates clustered into three genotypes: GA5, GA2, and GA1. Some strains clustered into the GA3 genotype characterized previously. The antigenic analysis was carried out with a panel of anti-G monoclonal antibodies that recognized conserved and strain-specific epitopes. A close correlation between the antigenic and genetic relatedness of the strains analyzed was observed. (C) 2003 Wiley-Liss, Inc.
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