Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 50, Issue 4, Pages 708-716Publisher
WILEY
DOI: 10.1002/mrm.10576
Keywords
cerebral oxygen extraction fraction; cerebral venous blood volume; hypercapnia; asymmetric spin echo
Funding
- NINDS NIH HHS [R01 NS054079, NS37312] Funding Source: Medline
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An asymmetric spin echo (ASE) single shot echo planar imaging (EPI) sequence is proposed for obtaining quantitative estimates of R2', cerebral venous blood volume fraction (vCBV), and oxygen extraction fraction (OEF) noninvasively in normal volunteers. The impact of the presence of intravascular signal on the estimates of vCBV and OEF were examined in five subjects with different levels of flow attenuation. A significant reduction in the estimates of vCBV and a small increase in the measurements of OEF were observed in the presence of flow suppression gradients. In addition, mild hypercapnia was induced in normal subjects (n = 4). R2', vCBV, and OEF were measured under both normocapnia and experimentally induced hypercapnia. In agreement with the well-documented cerebral vascular responses to hypercapnia, estimates of R2' and OEF decrease, while measures of vCBV increase during hypercapnia. (C) 2003 Wiley-Liss, Inc.
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