Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 27, Issue 7, Pages 1071-1079Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2003.09.003
Keywords
animal models; amphetamine; antipsychotics; paw test; phencyclidine; prepulse inhibition; schizophrenia
Funding
- NIDA NIH HHS [DA02925] Funding Source: Medline
- NIMH NIH HHS [MH42228, MH52885] Funding Source: Medline
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This review describes the animal behavior models that provide insight into the mechanisms underlying the critical differences between the actions of typical vs. atypical antipsychotic drugs. Although many of these models are capable of differentiating between antipsychotic and other psychotropic drugs, only a few seem to be able to differentiate between typical and atypical antipsychotics, such as the paw test and the phencyclidine (PCP)-induced disruption of prepulse inhibition (PPI) of startle in rats. Moreover, there is an urgent need for animal models focusing more on the negative and the cognitive symptoms. Hence, improved animal models are crucial for developing better treatments for schizophrenia. (C) 2003 Elsevier Inc. All rights reserved.
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