Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 15, Issue 5, Pages 544-552Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(03)00099-2
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Funding
- NIDDK NIH HHS [DK 49786] Funding Source: Medline
- PHS HHS [5T32 H007499] Funding Source: Medline
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The granzyme/perform pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems. This pathway is important in a variety of host defenses, including viral clearance and tumor cell killing, and its dysregulation results in several human and rodent diseases. To date, the majority of reports in this field have concentrated on the functions of granzymes A and B. Recent reports, however, suggest that the non-A/non-B 'orphan' granzymes found in both humans and mice are potentially significant. Although the functions of these orphan granzymes have yet to be fully established, initial data suggests their importance in both immune and nonimmune cells.
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