Journal
NEUROBIOLOGY OF AGING
Volume 24, Issue 6, Pages 861-863Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0197-4580(02)00226-9
Keywords
acetylcholine; prefrontal cortex; microdialysis; aging; potassium; rat
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Funding
- NIA NIH HHS [AG 10173] Funding Source: Medline
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Aging-related differences in the ability of cortical cholinergic inputs to respond to local depolarization was assessed in young (3-6 months) and old (26-33 months) awake rats using in vivo microdialysis in the absence of an inhibitor of acetylcholinesterase. Rats were perfused, using a within-subjects, repeated session design, with vehicle (aCSF) or K+ (25, 50, 100 mM). Perfusion of K+ resulted in a dose-dependent increase in cortical ACh efflux with comparable efflux seen between the two ages following 25 mM (50%) and 50 mM (100%) K+. In contrast, aged rats exhibited a marked attenuation (330%) in ACh efflux relative to young adult rats (650%). These data reveal aging-related decreases in the responsiveness of cortical cholinergic afferents, tested under physiologically relevant conditions, to local depolarization and may provide a neuronal mechanism contributing to the cognitive deficits reported in normal aging- and age-related pathological conditions. (C) 2002 Elsevier Science Inc. All rights reserved.
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