Journal
GENESIS
Volume 37, Issue 2, Pages 51-53Publisher
WILEY
DOI: 10.1002/gene.10225
Keywords
Cre/loxP; maternal deleter; recombination; mutant; Sox2Cre
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Funding
- NINDS NIH HHS [NS 33642] Funding Source: Medline
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The Sox2 gene is expressed in several undifferentiated cell types. In an earlier study we described a Sox2Cre transgene that mediates epiblast-specific Cre-mediated modification of gene activity in the embryo. Here we report that this transgene is active in the female germline. Consequently, all offspring that arise from female mice heterozygous for the Sox2Cre transgene have demonstrable Cre activity irrespective of whether they inherit the transgene itself. Maternal inheritance of Cre activity allows the efficient modification of gene activity for functional analysis. (C) 2003 Wiley-Liss, Inc.
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