Journal
ARCHIVES OF MICROBIOLOGY
Volume 194, Issue 9, Pages 779-784Publisher
SPRINGER
DOI: 10.1007/s00203-012-0813-2
Keywords
Acetyl-4; 4 '-Diapolycopene-4; 4 '-Dioate; Antioxidative property; C-30 biosynthesis pathway; Chemical modification
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Funding
- EU [207948]
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In a red bacterial strain SF238 belonging to Sporosarcina aquimarina, a C-30 carotenoid biosynthetic pathway was identified. It has been reconstructed by analysis of intermediates that accumulate in two different pigment mutants. It starts with the synthesis of 4,4'-diapophytoene and proceeds with its desaturation to 4,4'-diapolycopene, which is then oxidized to 4,4'-diapolycopene-4,4'-dioate. Using a combination of HPLC-PDA and LC-MS/MS analyses, the final product of this pathway was identified as acetyl-4,4'-diapolycopene-4,4'-dioate. This is a novel carotenoid not reported in any organisms to date. It could be demonstrated that this carotenoid has excellent antioxidative properties to protect from photosensitized peroxidation reactions like other related 4,4'-diapolycopene-4,4'-dioate derivatives.
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