Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 35, Issue 7, Pages 805-813Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(03)00428-3
Keywords
nano red elemental selenium (Nano-Se); free radicals; bovine serum albumin (BSA); size-dependent; nanoparticles-protein interactions
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In this study, we showed that smaller size particles of Nano-Se have better scavenging effects on the following free radicals: carbon-centered free radicals (R-.) generated from 2,2'-azo-bis-(2-amidinopropane) hydrochloride (AAPH), the relatively stable free radical 1,1-diphenyl-2-picryhydrazyl (DPPH), the superoxide anion (O-2(.-)) generated from the xanthine/xanthine oxioase (X/XO) system, singlet oxygen (O-1(2)) generated by irradiated hemoporphyrin. Furthermore, the three sizes of Nano-Se studied also show protective effects against the oxidation of DNA. The three samples all have potential size-dependent characteristics on scavenging the free radicals. Although in this study we regarded Nano-Se as a whole without considering interactions between BSA and the red selenium nano-particles, there is the possibility that the apparent free radical scavenging effects may be partially contributed by such interactions. (C) 2003 Elsevier Inc.
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