Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 14, Issue 5, Pages 427-446Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6101(03)00051-0
Keywords
PDGF-A; transcription; promoter; cancer; atherosclerosis; fibrosis
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Funding
- NCI NIH HHS [CA83237-02] Funding Source: Medline
- NHLBI NIH HHS [HL62877-01A1] Funding Source: Medline
- NIA NIH HHS [AG10836-06S1] Funding Source: Medline
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The molecular mechanisms which control the transcription of growth factor genes underlie such diverse biological processes as embryonic development, cellular differentiation and wound healing. Moreover, disruption of these controls is implicated in the development and progression of a wide variety of human diseases, including cancer, atherosclerosis and fibrotic disease. This review highlights progress made in the study of the gene encoding platelet-derived growth factor A-chain (PDGF-A) from the perspective of its normal patterns of expression, as well as possible mechanisms leading to dysregulation and disease. A particular focus has been placed on the identification and characterization of specific DNA elements, DNA-binding proteins and other aspects of transcriptional regulation involved in activation and repression of the human PDGF-A promoter. (C) 2003 Elsevier Ltd. All rights reserved.
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