Journal
EPILEPSY & BEHAVIOR
Volume 4, Issue -, Pages S14-S24Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2003.08.020
Keywords
epilepsy; affective disorder; serotonergic; noradrenergic; anticonvulsants; antidepressants
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Affective disorders and the epilepsies appear to share partially similar pathogenic mechanisms. Predisposition to both disorders is determined genetically and experientially. A component of the shared predisposition appears to arise from noradrenergic and serotonergic deficits. Shared GABAergic deficits coupled with CRHergic and glutamatergic excesses may trigger and maintain seizures as well as dysfunctional affective episodes, albeit via dissimilar neuronal interplay. (C) 2003 Elsevier Inc. All rights reserved.
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