Journal
INFLAMMATION
Volume 27, Issue 5, Pages 265-280Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1026056525755
Keywords
L-Selectin ligands/counter-receptors; fucosyltransferases; MECA 79; MECA 367; sulfotransferases; PNAd; MAdCAM-1; PCLP; GlyCAM-1; CD34; PSGL-1; sLex; fucoidan; chondroitin sulfate; versican; heparan sulfate; VAP-1; high endothelial venules (HEV)
Categories
Ask authors/readers for more resources
Both lymphocyte recirculation through the lymphoid tissues and leukocyte recruitment to sites of inflammation are essential components of immune surveillance, and are necessary for sustained protection against pathogens. This process is mediated by the leukocyte-endothelial adhesion cascade of which the interaction of leukocyte L-Selectin with its endothelial ligand initiates the first critical tethering and rolling step. As well as discussing the constitutive L-Selectin ligands in lymphoid tissues, this review examines the literature regarding their induction in inflammation, and draws attention to recent findings regarding soluble L-Selectin ligands that suggest an emerging multifunctional role in leukocyte recirculation and inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available