Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 10, Pages 1324-1327Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030277n
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Funding
- NCI NIH HHS [CA17624] Funding Source: Medline
- NIAID NIH HHS [AI33066] Funding Source: Medline
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Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.
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