Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 188, Issue 7, Pages 948-953Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/378503
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Funding
- NCI NIH HHS [CA89567] Funding Source: Medline
- NIAID NIH HHS [AI50583, AI55602] Funding Source: Medline
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An 11-year-old girl presented with a papulovesicular rash and severe respiratory distress 5 weeks after receiving varicella vaccine. Restriction fragment length - polymorphism analysis of virus isolated from an endotracheal-tube aspirate and from bronchoalveolar lavage revealed that this patient's illness was due to the Oka vaccine strain of varicella. An extensive immunologic analysis failed to identify a known diagnostic entity to explain her susceptibility to this attenuated vaccine strain. Analysis of her lymphocytes on separate occasions, months after recovery from her illness, revealed a profound deficiency of natural killer T (NKT) cells and of NKT-cell activity, suggesting that NKT cells contribute to host defense against varicella virus.
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