Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 13, Issue 5, Pages 558-569Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2003.09.007
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Few biological macromolecular complexes exhibit the combination of massive size and hierarchical, symmetrical architecture embodied in icosahedral viruses. X-ray crystallography, electron cryomicroscopy and small-angle X-ray scattering provide complementary approaches to studying these remarkable structures. Through a combined approach, progress has been made towards providing detailed structures of highly complex and very large viruses, and towards imaging the dynamic structural changes performed by viruses at key stages in their life cycles.
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