Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 23, Issue 19, Pages 6936-6943Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.23.19.6936-6943.2003
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Funding
- NIGMS NIH HHS [R01 GM059172, GM59172] Funding Source: Medline
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Plk2 (Snk) is a polo-like kinase expressed at G, in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is diminished in Plk2(-/-) embryos due to decreased cell proliferation. Cultured Plk2(-/-) embryonic fibroblasts grow more slowly than normal cells and show delayed entry into S phase. These data suggest a role for Plk2 in the cell cycle.
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